Permanent neurological sequelae despite haemodialysis for lithium intoxication.
نویسندگان
چکیده
THREE PATIENTS WITH LITHIUM TOXICITY ARE REPORTED, TWO OF WHOM WERE EXPOSED TO TOXIC LITHIUM LEVELS FOR A PROLONGED PERIOD: both survived with permanent damage to basal ganglia and cerebellar connexions despite effective lowering of lithium levels by haemodialysis. Data obtained during dialysis treatment show prolonged haemodialysis to be the treatment of choice. If facilities for haemodialysis are not available or the patient presents with toxic lithium levels and minimal symptoms peritoneal dialysis will effectively lower serum lithium levels, but more slowly than haemodialysis.
منابع مشابه
Lithium-Neuroleptic Combination Leading to Permanent Neurological Sequelae?
There has been considerable debate regarding the safety of lithium and neuroleptics combination in patients. The resulting neurotoxicity causes persistent sequelae resulting in significant impairment when compared to the effects when lithium or neuroleptics are taken alone. This report describes the case of a 28-year old young man with bipolar disorder who developed residual neurological defici...
متن کاملCerebellar Damage in a Patient on Lithium Developing Enteric Fever : a Case Report
The effects of lithium on the CNS range from commonly observed mild effects to life threatening, irreversible brain damage in rare instances of severe toxicity (Moore 1972, Hartitzach et al 1972, Reisberg & Gershon 1979, Kadgoanker et al 1981). Some of the common side effects include mild cognitive impairment, muscular weakness, tremors and EEG changes. Neurotoxicity usually presents with cloud...
متن کاملLithium intoxication: Incidence, clinical course and renal function – a population-based retrospective cohort study
When prescribing lithium, the risk of toxicity remains a concern. In this study, we examined a cohort of patients exposed to lithium between 1997 and 2013. The aims of this study were to determine the frequency of lithium intoxication and to evaluate the clinical course and changes in renal function. Of 1340 patients, 96 had experienced at least one episode of lithium levels ⩾1.5 mmol/L, yieldi...
متن کاملPersistent lithium-induced neurotoxicity: direct effect of lithium and/or hypernatremia?
Abstract Lithium has been used in the treatment of bipolar affective disorder (BAD) for more than 50 years. Features of lithium toxicity include drowsiness, slurred speech, ataxia, psychomotor slowing, polyneuropathy, impaired memory, seizures, coma and death. Lithium neurotoxicity is usually reversible on cessation of its administration, and irreversible toxicity is uncommon. However, persiste...
متن کاملA Creutzfeldt-Jakob like syndrome due to lithium toxicity.
Two patients with lithium toxicity presented with a neurological syndrome suggesting a diagnosis of Creutzfeldt-Jakob disease. In both cases, the initial EEG was consistent with this diagnosis. Neither patient had permanent neurological sequelae and the EEG returned to normal. A careful drug history should be taken in any patient who presents with a rapidly progressive dementia even when the EE...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British medical journal
دوره 4 5843 شماره
صفحات -
تاریخ انتشار 1972